Description
Design and conduct preclinical and clinical pharmacology research to understand how drugs affect biological systems and to improve human health. Characterize mechanisms, efficacy, safety, and ADME; model PK/PD; and translate findings into optimized therapies and dosing strategies.
- • Plan and direct pharmacology studies to assess drug mechanisms, efficacy, and safety in human and animal models.
- • Follow GLP/GCP and strict safety procedures when handling hazardous chemicals, bioagents, and controlled substances.
- • Evaluate pharmacodynamic, pharmacokinetic, and toxic effects of candidates at molecular, cellular, organ, and whole-organism levels.
- • Teach pharmacology principles, PK/PD modeling, and laboratory procedures to clinicians, students, and technicians.
- • Prepare and analyze biological matrices to quantify drug and metabolite levels, metabolism, and receptor binding.
- • Standardize dosing regimens, formulations, and routes of administration; develop study protocols and SOPs.
- • Investigate drug targets, mechanisms of action, resistance, and drug–drug interactions affecting outcomes.
- • Collaborate with clinicians, toxicologists, chemists, and regulatory teams to define safety margins and therapeutic guidelines.
- • Study physiology and pathophysiology relevant to target pathways and therapeutic indications.
- • Advise researchers and clinicians on applications of pharmacology, chemistry, and biology to medical practice and research.
- • Operate LC-MS/MS, HPLC, flow cytometers, microplate readers, electrophysiology, and imaging systems for assays.
- • Develop and validate assays, biomarkers, and models; perform PK/PD and exposure–response analyses and present findings.
- • Write and publish pharmacology research in peer-reviewed journals and at scientific meetings.
- • Prepare grant proposals, study protocols, and regulatory documents such as IND/CTA sections.
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Healthcare & Human Services
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O*NET occupational data (work activities, skills, knowledge).
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Last reviewed: Jan 2026
