Description
Assess and research the adverse effects of chemicals, drugs, and other agents on humans, animals, and ecosystems. Design and conduct studies to elucidate mechanisms of toxicity, dose-response, and toxicokinetics, and determine safe exposure limits. Evaluate and communicate risks, support product development and regulatory compliance, and recommend hazard controls and remediation.
- • Prepare risk assessments, study reports, and safety recommendations based on toxicological data.
- • Develop in vitro and in vivo models to investigate mechanisms of toxicity.
- • Manage laboratory teams and ensure GLP and QA compliance.
- • Publish findings and present toxicology data at scientific and regulatory meetings.
- • Develop or validate assays to detect toxicants, biomarkers of exposure, or organ-specific injury.
- • Design and oversee nonclinical safety studies for drugs, chemicals, or consumer products.
- • Investigate genotoxicity, carcinogenicity, reproductive and developmental toxicity.
- • Characterize chemical structures and metabolites using LC-MS/MS, GC-MS, or NMR.
- • Study absorption, distribution, metabolism, and excretion (ADME) and toxicokinetics.
- • Model dose-response relationships and derive health-based exposure limits.
- • Support formulation and impurity qualification and safety evaluations.
- • Research interactions of drugs, contaminants, or mixtures with biological targets and pathways.
- • Evaluate ecological and environmental toxicity in soil, water, or air systems.
- • Develop methods and SOPs for sample collection, processing, and chain of custody.
- • Investigate gene expression and pathway perturbations related to toxic responses.
- • Apply quantitative structure-activity relationships (QSAR) and read-across for hazard prediction.
- • Prepare and qualify reference standards and positive controls for toxicology assays.
- • Design or adapt exposure systems and analytical setups for inhalation, dermal, or oral studies.
- • Teach, mentor, or supervise students and junior staff in toxicology techniques.
- • Conduct isotope tracing or proteomic/metabolomic studies to map toxicant transformations.
- • Examine immunotoxicity and hypersensitivity reactions.
- • Maintain and calibrate laboratory instruments and safety equipment for specialized studies.
- • Prepare regulatory submissions and dossiers (e.g., IND, NDA, REACH, EPA) to support approvals.
- • Write grant proposals or funding applications for toxicology research.
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Advanced Manufacturing
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Tasks & skills:
O*NET occupational data (work activities, skills, knowledge).
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This site includes information from O*NET by the U.S. Department of Labor, Employment and Training Administration (USDOL/ETA), used under the CC BY 4.0 license. Career Clutch has modified some of this information for student readability. USDOL/ETA has not approved, endorsed, or tested these modifications. O*NET® is a trademark of USDOL/ETA.
Last reviewed: Jan 2026
